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KMID : 0881720000150030267
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Journal of Food Hygiene and Safety
2000 Volume.15 No. 3 p.267 ~ p.270
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Application of Mathematical Modeling to Extraplate from High Dose to Low Dose for Risk Assessment of Vinyl Chloride
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Lee Young-Jo
Lee Seok-Ho
Lee Seung -Jin
Chung Jin-Ho
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Abstract
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This study was designed to predict the risk of a hazard chemical, vinyl chloride, by applying dose-response assessment that are one of the major process in practicing risk assessment. After extrapolating from the high dose exposure of vinyl chloride based upon animal carcinogenic data to the low dose exposed to human using several mathematical models, we calculated the cancer potency factors as well as virtually safe dose and the resulted values were compared. This process will provide the new insight to assess the risk of a chemical accurately imposed to human in the future.
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KEYWORD
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Vinyl chloride, Mathematical modeling, Risk assessment, Carcinogens
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